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    tat-1 Phospholipid-transporting ATPase tat-1 [ Caenorhabditis elegans ]

    Gene ID: 176666, updated on 9-Dec-2024

    Summary

    Official Symbol
    tat-1
    Official Full Name
    Phospholipid-transporting ATPase tat-1
    Primary source
    WormBase:WBGene00013034
    Locus tag
    CELE_Y49E10.11
    See related
    AllianceGenome:WB:WBGene00013034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including lysosome organization; phospholipid translocation; and regulation of phagocytosis, engulfment. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and endosome. Is expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4. Orthologous to several human genes including ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See tat-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    20
    Sequence:
    Chromosome: III; NC_003281.10 (12398901..12421718, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Proteoglycan 4 Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene Pharynx and intestine in excess protein 1 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene putative small nuclear ribonucleoprotein E

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine floppase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Phospholipid-transporting ATPase tat-1
    NP_001022894.1
    • Confirmed by transcript evidence
    NP_001255165.1
    • Confirmed by transcript evidence
    NP_001367088.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12398901..12421718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027723.3NP_001022894.1  Phospholipid-transporting ATPase tat-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0P289, Q7JK70, Q9U280
      Conserved Domains (5) summary
      TIGR01652
      Location:281036
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:446545
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:1679
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:7911043
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:745789
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. NM_001268236.3NP_001255165.1  Phospholipid-transporting ATPase tat-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U280
      Conserved Domains (6) summary
      TIGR01652
      Location:281036
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:85178
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:446545
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:1679
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:7911043
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:745789
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    3. NM_001379952.2NP_001367088.1  Phospholipid-transporting ATPase tat-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd02073
      Location:30922
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C