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    sdc-2 Sex determination and dosage compensation protein sdc-2 [ Caenorhabditis elegans ]

    Gene ID: 181341, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sdc-2
    Official Full Name
    Sex determination and dosage compensation protein sdc-2
    Primary source
    WormBase:WBGene00004746
    Locus tag
    CELE_C35C5.1
    See related
    AllianceGenome:WB:WBGene00004746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sdc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (11522707..11533450)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein;ZM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Saposin B-type domain-containing protein Neighboring gene Group-specific protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation. Albritton SE, et al. Elife, 2017 May 30. PMID 28562241, Free PMC Article
    2. Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate. Dawes HE, et al. Science, 1999 Jun 11. PMID 10364546
    3. Worm chromosomes call for recognition! Rattner BP, et al. Bioessays, 2004 Jul. PMID 15221851
    4. xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision. Rhind NR, et al. Cell, 1995 Jan 13. PMID 7813020
    5. Genome-wide analysis of condensin binding in Caenorhabditis elegans. Kranz AL, et al. Genome Biol, 2013. PMID 24125077, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dosage compensation by hypoactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sex determination and dosage compensation protein sdc-2
    NP_509924.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11522707..11533450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077523.7 → NP_509924.1  Sex determination and dosage compensation protein sdc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509924.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBL3
      Conserved Domains (1) summary
      cl26511
      Location:1085 → 1392
      Neuromodulin_N; Gap junction protein N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBL3.1

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