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    nob-1 Homeobox protein nob-1 [ Caenorhabditis elegans ]

    Gene ID: 176641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nob-1
    Official Full Name
    Homeobox protein nob-1
    Primary source
    WormBase:WBGene00003779
    Locus tag
    CELE_Y75B8A.2
    See related
    AllianceGenome:WB:WBGene00003779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of miRNA transcription; and positive regulation of nematode male tail tip morphogenesis. Located in nucleus. Is expressed in several structures, including head muscle; intestine; linker cell; nervous system; and tail. Orthologous to several human genes including HOXA9 (homeobox A9); HOXB9 (homeobox B9); and HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nob-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (12077793..12084316, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase Neighboring gene Homeobox protein php-3 Neighboring gene ncRNA Neighboring gene Carboxylesterase type B domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A negative regulatory loop between microRNA and Hox gene controls posterior identities in Caenorhabditis elegans. Zhao Z, et al. PLoS Genet, 2010 Sep 2. PMID 20824072, Free PMC Article
    2. The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development. Chen Z, et al. Mol Cell Biol, 2004 Sep. PMID 15314147, Free PMC Article
    3. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes. Van Auken K, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781051, Free PMC Article
    4. Hox Gene Loss during Dynamic Evolution of the Nematode Cluster. Aboobaker AA, et al. Curr Biol, 2003 Jan 8. PMID 12526742
    5. Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans. Zheng C, et al. Neuron, 2015 Nov 4. PMID 26539892, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of miRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein nob-1
    NP_001367008.1
    • Confirmed by transcript evidence
    NP_001369824.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12077793..12084316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383007.2 → NP_001369824.1  Homeobox protein nob-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFY5, G5EGL1, Q7K756, Q7KKJ1
      Conserved Domains (1) summary
      pfam00046
      Location:165 → 219
      Homeobox; Homeobox domain

    2. NM_001379944.1 → NP_001367008.1  Homeobox protein nob-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00046
      Location:14 → 68
      Homeobox; Homeobox domain

    RNA

    1. NR_147825.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFY5.2

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