drag-1 Repulsive guidance molecule B homolog drag-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: drag-1
Official Full Name: Repulsive guidance molecule B homolog drag-1
Primary source: WormBase:WBGene00022154
Locus tag: CELE_Y71G12B.16
See related: AllianceGenome:WB:WBGene00022154
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable coreceptor activity. Involved in several processes, including mesodermal cell fate specification; regulation of BMP signaling pathway; and regulation of dauer larval development. Located in plasma membrane. Part of receptor complex. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in hemochromatosis; hemochromatosis type 2A; and multiple sclerosis. Orthologous to several human genes including HJV (hemojuvelin BMP co-receptor) and RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See drag-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (1680446..1685203)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans.
Title: The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71G12A_200.a (e-PCR)
- UniSTS:323300

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Repulsive guidance molecule B homolog drag-1

NP_490881.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1680446..1685203

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058480.6 → NP_490881.4 Repulsive guidance molecule B homolog drag-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490881.4

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDE5

Conserved Domains (2) summary

pfam06534
Location:184 → 356

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:22 → 167

RGM_N; Repulsive guidance molecule (RGM) N-terminus