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    nekl-1 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 189769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nekl-1
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00021461
    Locus tag
    CELE_Y39G10AR.3
    See related
    AllianceGenome:WB:WBGene00021461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in amphid neurons and lumbar neurons. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome; nephronophthisis 9; and renal-hepatic-pancreatic dysplasia. Orthologous to several human genes including NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nekl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (2357883..2372985)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Synaptic defective enhancer 1 Neighboring gene Histone-lysine N-methyltransferase, H3 lysine-79 specific

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects. Casey JP, et al. Hum Mol Genet, 2016 May 1. PMID 26908619
    2. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Seidel HS, et al. Science, 2008 Feb 1. PMID 18187622, Free PMC Article
    3. CDKL kinase regulates the length of the ciliary proximal segment. Park K, et al. Curr Biol, 2021 Jun 7. PMID 33857430
    4. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_001293320.1
    • Partially confirmed by transcript evidence
    NP_001293321.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2357883..2372985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306391.3 → NP_001293320.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD48
      Conserved Domains (2) summary
      COG5184
      Location:449 → 764
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08215
      Location:170 → 423
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

    2. NM_001306392.3 → NP_001293321.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJL2
      Conserved Domains (2) summary
      COG5184
      Location:411 → 726
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08215
      Location:132 → 385
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

    RNA

    1. NR_131356.1 RNA Sequence

      Status: REVIEWED

    2. NR_131355.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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