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    vha-11 V-type proton ATPase subunit C [ Caenorhabditis elegans ]

    Gene ID: 177017, updated on 2-Nov-2024

    Summary

    Official Symbol
    vha-11
    Official Full Name
    V-type proton ATPase subunit C
    Primary source
    WormBase:WBGene00006920
    Locus tag
    CELE_Y38F2AL.3
    See related
    AllianceGenome:WB:WBGene00006920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development and ovulation. Predicted to be located in cytoplasm and membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in excretory cell; hypodermis; and intestinal cell. Orthologous to several human genes including ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See vha-11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (2307815..2314567, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene B9 domain-containing protein 2 Neighboring gene ncRNA Neighboring gene V-type proton ATPase 16 kDa proteolipid subunit 2/3 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables proton transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase subunit C
    NP_001023451.1
    • Confirmed by transcript evidence
    NP_001367641.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2307815..2314567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028280.6NP_001023451.1  V-type proton ATPase subunit C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q869J4, Q9N421, Q9XXU9
      Conserved Domains (2) summary
      cd14785
      Location:5878
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:10373
      V-ATPase_C; V-ATPase subunit C
    2. NM_001380087.1NP_001367641.1  V-type proton ATPase subunit C [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl15414
      Location:1098
      V-ATPase_C; Subunit C of vacuolar H+-ATPase (V-ATPase)