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    nuo-6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 172438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nuo-6
    Official Full Name
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
    Primary source
    WormBase:WBGene00012166
    Locus tag
    CELE_W01A8.4
    See related
    AllianceGenome:WB:WBGene00012166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane and mitochondrion. Predicted to be part of respiratory chain complex I. Is expressed in body wall musculature; germ line; gonad; hypodermis; and intestine. Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nuo-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (7068116..7069186, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene Twenty One u-rna (21U-RNA) biogenesis Fouled Up Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pharynx mitochondrial [Ca(2+)] dynamics in live C. elegans worms during aging. Alvarez-Illera P, et al. Oncotarget, 2017 Aug 22. PMID 28915560, Free PMC Article
    2. Long-term monitoring of Ca2+ dynamics in C. elegans pharynx: an in vivo energy balance sensor. Alvarez-Illera P, et al. Oncotarget, 2016 Oct 18. PMID 27661127, Free PMC Article
    3. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. Yang W, et al. PLoS Biol, 2010 Dec 7. PMID 21151885, Free PMC Article
    4. Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant. Pujol C, et al. PLoS One, 2013. PMID 23555681, Free PMC Article
    5. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Yee C, et al. Cell, 2014 May 8. PMID 24813612, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROS production by mitochondrial mutants and found that isp-1 and nuo-6 mutants have increased generation of the superoxide anion but not increased levels of other ROS and that this increase is necessary and sufficient for longevity.
      Title: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
    2. found that the lifespan increase induced by nuo-6(RNAi) is fully additive to that induced by isp-1(qm150), and the increase induced by isp-1(RNAi) is fully additive to that induced by nuo-6(qm200)[nuo-6]
      Title: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.
    3. The GCN-2 pathway was not required for the longevity phenotype of nuo-6 worms.
      Title: The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
    NP_492001.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7068116..7069186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059600.6 → NP_492001.2  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492001.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23098
      Conserved Domains (1) summary
      pfam07225
      Location:39 → 155
      NDUF_B4; NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
    Nucleotide Protein
    Heading Accession and Version

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