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    F25H8.2 H/ACA ribonucleoprotein complex non-core subunit NAF1 [ Caenorhabditis elegans ]

    Gene ID: 177848, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F25H8.2
    Official Full Name
    H/ACA ribonucleoprotein complex non-core subunit NAF1
    Primary source
    WormBase:WBGene00009132
    Locus tag
    CELE_F25H8.2
    See related
    AllianceGenome:WB:WBGene00009132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in box H/ACA snoRNP assembly and ribosome biogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human NAF1 (nuclear assembly factor 1 ribonucleoprotein). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See F25H8.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (9932235..9933879)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Zinc finger BED domain-containing protein 3 Neighboring gene Dauer Up-Regulated Neighboring gene tRNA methyltransferase 10 homolog A Neighboring gene Uncharacterized protein Neighboring gene A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in box H/ACA snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box H/ACA snoRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H/ACA ribonucleoprotein complex non-core subunit NAF1
    NP_501790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9932235..9933879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069389.6 → NP_501790.1  H/ACA ribonucleoprotein complex non-core subunit NAF1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19788
      Conserved Domains (1) summary
      pfam04410
      Location:149 → 306
      Gar1; Gar1/Naf1 RNA binding region
    Nucleotide Protein
    Heading Accession and Version

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