U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nuaf-3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [ Caenorhabditis elegans ]

    Gene ID: 187686, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nuaf-3
    Official Full Name
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
    Primary source
    WormBase:WBGene00011123
    Locus tag
    CELE_R07H5.3
    See related
    AllianceGenome:WB:WBGene00011123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nuaf-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (11184291..11186012)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RAP homolog (vertebrate Rap GTPase family) Neighboring gene Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. Chuaijit S, et al. Mitochondrion, 2019 May. PMID 29540318
    2. Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans. van den Ecker D, et al. Mitochondrion, 2012 May. PMID 22387847
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate that two candidates (C50B8.3/NUAF-1, homologue of NDUFAF1 and R07H5.3/NUAF-3, homologue of NDUFAF3) clearly affect complex I function.
      Title: Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
    NP_001023328.1
    • Confirmed by transcript evidence
    NP_001129864.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11184291..11186012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028157.5 → NP_001023328.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93931
      Conserved Domains (1) summary
      cd05125
      Location:72 → 186
      Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...

    2. NM_001136392.4 → NP_001129864.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2MZC3
      Conserved Domains (1) summary
      cd05125
      Location:22 → 136
      Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous