smg-9 Nonsense-mediated mRNA decay factor SMG9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smg-9
Official Full Name: Nonsense-mediated mRNA decay factor SMG9
Primary source: WormBase:WBGene00013188
Locus tag: CELE_Y54E2A.2
See related: AllianceGenome:WB:WBGene00013188
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables molecular sequestering activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Orthologous to human SMG9 (SMG9 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See smg-9 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (14747793..14752489, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found that SMG8-SMG9 is a G-domain heterodimer with architectural similarities to the dynamin-like family of GTPases. The SMG8-SMG9 heterodimer forms in the absence of nucleotides. Nucleotide binding occurs at the G domain of SMG9 but not of SMG8.
Title: Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y54E2A.2 (e-PCR)
- UniSTS:320416

Y54E2A.3 (e-PCR)
- UniSTS:313002

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular sequestering activity	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Nonsense-mediated mRNA decay factor SMG9

NP_497058.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14747793..14752489 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064657.4 → NP_497058.1 Nonsense-mediated mRNA decay factor SMG9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497058.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XWJ1

Conserved Domains (1) summary

cl21455
Location:88 → 108

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases