rga-6 Rho-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rga-6
Official Full Name: Rho-GAP domain-containing protein
Primary source: WormBase:WBGene00015303
Locus tag: CELE_C01F4.2
See related: AllianceGenome:WB:WBGene00015303
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in defense response to fungus. Is expressed in intestine and nervous system. Used to study long QT syndrome. Orthologous to human ARHGAP36 (Rho GTPase activating protein 36) and ARHGAP6 (Rho GTPase activating protein 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rga-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (4850666..4867825, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rho-GTPase activating protein 6 is novel HERG regulator
Title: Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.

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General gene information

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Markers

C01F4.1 (e-PCR)
- UniSTS:318980

F57C9.8 (e-PCR)
- UniSTS:311913

C01F4.3 (e-PCR)
- UniSTS:321899

C01F4.2 (e-PCR)
- UniSTS:319983

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rho-GAP domain-containing protein

NP_491465.2

Confirmed by transcript evidence

NP_491466.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4850666..4867825 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059064.9 → NP_491465.2 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491465.2

Status: REVIEWED

UniProtKB/TrEMBL

O01443, O01444

Conserved Domains (1) summary

cd04376
Location:520 → 724

RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...
NM_059065.7 → NP_491466.2 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491466.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KYD2

Conserved Domains (1) summary

cl02570
Location:520 → 617

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...