unc-103 Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-103
Official Full Name: Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103
Primary source: WormBase:WBGene00006830
Locus tag: CELE_C30D11.1
See related: AllianceGenome:WB:WBGene00006830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to several human genes including KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-103 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 22

Sequence:: Chromosome: III; NC_003281.10 (4115385..4147278)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function mutations of cnx-1 decreased the protein level and current density of the UNC-103 K(+) channel and suppressed the behavioral defects caused by a gain-of-function mutation in unc-103 Moreover, CNX-1 facilitated tetrameric assembly of UNC-103 channel subunits in a liposome-assisted cell-free translation system.
Title: A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K(+) channels.
ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG K+ channels. They regulate two distinct aspects of K+ channel biogenesis, the stabilization and assembly of channel subunits.
Title: Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.
rho-GTPase activating protein 6 is novel regulator of HERG homolog UNC-103
Title: Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.
UNC-103 regulates contractile behaviors of sex muscles in males before and during mating.
Title: Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-134 (e-PCR)
- UniSTS:241974

C30D11.1 (e-PCR)
- UniSTS:313776

C30D11.2 (e-PCR)
- UniSTS:317924

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of egg-laying behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103

NP_001122687.1

Partially confirmed by transcript evidence

NP_001293649.1

Confirmed by transcript evidence

NP_001366693.1

Partially confirmed by transcript evidence

NP_001367165.1

Partially confirmed by transcript evidence

NP_001367166.1

Partially confirmed by transcript evidence

NP_001367167.1

Partially confirmed by transcript evidence

NP_001367168.1

Confirmed by transcript evidence

NP_001368173.1

Partially confirmed by transcript evidence

NP_001370238.1

Confirmed by transcript evidence

NP_001370239.1

Confirmed by transcript evidence

NP_001382275.1

Confirmed by transcript evidence

NP_001407487.1

Confirmed by transcript evidence

NP_001407488.1

Confirmed by transcript evidence

NP_001407489.1

Confirmed by transcript evidence

NP_001407490.1

Confirmed by transcript evidence

NP_001407491.1

Confirmed by transcript evidence

NP_001407492.1

Confirmed by transcript evidence

NP_001407493.1

Partially confirmed by transcript evidence

NP_001407494.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4115385..4147278

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306720.3 → NP_001293649.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293649.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFJ9

Conserved Domains (4) summary

COG0664
Location:375 → 459

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:374 → 485

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:63 → 300

Ion_trans; Ion transport protein

pfam07885
Location:243 → 297

Ion_trans_2; Ion channel
NM_001384063.2 → NP_001370238.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECG3, G5EDE3, G5EE47, G5EFJ9, G5EFT6, G5EG15, G5EG91, G5EGQ1, M1Z8A0, M1ZJW5

Conserved Domains (1) summary

PLN03192
Location:121 → 544

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001420612.1 → NP_001407487.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZGA2
NM_001395354.1 → NP_001382275.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZF36

Conserved Domains (1) summary

PLN03192
Location:55 → 478

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001420613.1 → NP_001407488.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZEP4
NM_001420614.1 → NP_001407489.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZGL5
NM_001381818.1 → NP_001367165.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:113 → 536

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001381819.1 → NP_001367166.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:155 → 578

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001381820.1 → NP_001368173.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:190 → 613

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001381821.1 → NP_001367167.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:97 → 520

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001420615.1 → NP_001407490.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZGB1
NM_001381822.1 → NP_001367168.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:93 → 516

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001420616.1 → NP_001407491.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZEY3
NM_001420617.1 → NP_001407492.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZEU0
NM_001384064.1 → NP_001370239.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:83 → 506

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001381823.1 → NP_001366693.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN03192
Location:83 → 506

PLN03192; Voltage-dependent potassium channel; Provisional
NM_001129215.1 → NP_001122687.1 Potassium voltage-gated channel unc-103 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122687.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFJ9

Conserved Domains (4) summary

COG0664
Location:421 → 505

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:420 → 531

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:109 → 346

Ion_trans; Ion transport protein

pfam07885
Location:289 → 343

Ion_trans_2; Ion channel
NM_001420618.1 → NP_001407493.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D7ZEX1
NM_001420619.1 → NP_001407494.1 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D8EJ82