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    sms-2 Phosphatidylcholine:ceramide cholinephosphotransferase 2 [ Caenorhabditis elegans ]

    Gene ID: 180445, updated on 9-Dec-2024

    Summary

    Official Symbol
    sms-2
    Official Full Name
    Phosphatidylcholine:ceramide cholinephosphotransferase 2
    Primary source
    WormBase:WBGene00004893
    Locus tag
    CELE_F53H8.4
    See related
    AllianceGenome:WB:WBGene00004893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See sms-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (944826..948883, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Schwannomin interacting protein 1 C-terminal domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Beta-arrestin arr-1 Neighboring gene AP-3 complex subunit mu

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ceramide cholinephosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingomyelin synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sphingomyelin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingomyelin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingomyelin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Phosphatidylcholine:ceramide cholinephosphotransferase 2
    NP_508182.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      944826..948883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075781.6NP_508182.1  Phosphatidylcholine:ceramide cholinephosphotransferase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20735
      Conserved Domains (1) summary
      pfam14360
      Location:201273
      PAP2_C; PAP2 superfamily C-terminal