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    rnf-1 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnf-1
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00004380
    Locus tag
    CELE_C06A5.9
    See related
    AllianceGenome:WB:WBGene00004380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Orthologous to human RNF183 (ring finger protein 183). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rnf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (6009782..6011586, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LEM-like domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein Neighboring gene Integrator complex subunit 1 RPB2-binding domain-containing protein Neighboring gene ncRNA Neighboring gene COP9 signalosome complex subunit 2 Neighboring gene ncRNA Neighboring gene DUF4044 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1. Crowe E, et al. Dev Biol, 2004 Jan 15. PMID 14732404
    2. DREAM interrupted: severing LIN-35-MuvB association in Caenorhabditis elegans impairs DREAM function but not its chromatin localization. Goetsch PD, et al. Genetics, 2022 Jul 4. PMID 35554539, Free PMC Article
    3. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
    4. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Required for L1 development, vulval development, and for egg laying.
      Title: Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_491738.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6009782..6011586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059337.5 → NP_491738.2  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491738.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01482
      Conserved Domains (2) summary
      cd00162
      Location:22 → 67
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:22 → 68
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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