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    tbc-16 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180856, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-16
    Official Full Name
    Rab-GAP TBC domain-containing protein
    Primary source
    WormBase:WBGene00018639
    Locus tag
    CELE_F49E10.1
    See related
    AllianceGenome:WB:WBGene00018639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be active in early endosome. Is expressed in nervous system. Orthologous to human TBC1D16 (TBC1 domain family member 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-16 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    17
    Sequence:
    Chromosome: X; NC_003284.9 (5897338..5902157)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Carotenoid oxygenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Wang C, et al. Neurobiol Dis, 2018 Jan. PMID 28982592
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rab-GAP TBC domain-containing protein
    NP_508988.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5897338..5902157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076587.7 → NP_508988.3  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508988.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20600
      Conserved Domains (2) summary
      smart00164
      Location:415 → 644
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:32 → 136
      DUF3548; Domain of unknown function (DUF3548)
    Nucleotide Protein
    Heading Accession and Version

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