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    sax-2 MOR2-PAG1_N domain-containing protein;Protein furry C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sax-2
    Official Full Name
    MOR2-PAG1_N domain-containing protein;Protein furry C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00004728
    Locus tag
    CELE_F21H11.2
    See related
    AllianceGenome:WB:WBGene00004728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in neuron projection development. Predicted to be active in cell cortex and site of polarized growth. Is expressed in head neurons; tail neurons; and ventral nerve cord. Orthologous to human FRYL (FRY like transcription coactivator) and FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sax-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    34
    Sequence:
    Chromosome: III; NC_003281.10 (5109701..5130676)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Cuticle collagen dpy-17 Neighboring gene T-box protein 2 Neighboring gene Protein HGH1 homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase. Gallegos ME, et al. Neuron, 2004 Oct 14. PMID 15473964
    2. Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Zallen JA, et al. Mol Biol Cell, 2000 Sep. PMID 10982409, Free PMC Article
    3. The cell cortex-localized protein CHDP-1 is required for dendritic development and transport in C. elegans neurons. Zhao T, et al. PLoS Genet, 2022 Sep. PMID 36126047, Free PMC Article
    4. Temporally regulated cell migration is sensitive to variation in body size. Dubois C, et al. Development, 2021 Mar 5. PMID 33593818, Free PMC Article
    5. Genes required for axon pathfinding and extension in the C. elegans nerve ring. Zallen JA, et al. Development, 1999 Aug. PMID 10409513

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOR2-PAG1_N domain-containing protein;Protein furry C-terminal domain-containing protein
    NP_741131.2
    • Confirmed by transcript evidence
    NP_741132.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5109701..5130676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171117.5 → NP_741131.2  MOR2-PAG1_N domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5DX48, Q5UBX5
      Conserved Domains (2) summary
      pfam14222
      Location:154 → 682
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:1944 → 2201
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    2. NM_171118.6 → NP_741132.2  Protein furry C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741132.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZU6
    Nucleotide Protein
    Heading Accession and Version

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