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    Mzf1 myeloid zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 109889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mzf1provided by MGI
    Official Full Name
    myeloid zinc finger 1provided by MGI
    Primary source
    MGI:MGI:107457
    See related
    Ensembl:ENSMUSG00000030380 AllianceGenome:MGI:107457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mzf2; Mzf-2; Zfp98; Znf42; Zfp121
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in bladder; central nervous system; male associated reproductive structure; testis; and urethra of male. Orthologous to human MZF1 (myeloid zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 1.8), frontal lobe adult (RPKM 1.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mzf1 in Genome Data Viewer
    Location:
    7 A1; 7 7.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12777074..12792244, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13042303..13054764, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:13619992-13620293 Neighboring gene charged multivesicular body protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E6513 Neighboring gene ubiquitin-conjugating enzyme E2M Neighboring gene STARR-positive B cell enhancer ABC_E2223 Neighboring gene STARR-seq mESC enhancer starr_18069 Neighboring gene vomeronasal 1 receptor 85 Neighboring gene predicted gene 4270

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway. Qu Z, et al. J Leukoc Biol, 2024 Apr 29. PMID 38266238
    2. A novel form of the myeloid-specific zinc finger protein (MZF-2). Murai K, et al. Genes Cells, 1997 Sep. PMID 9413999
    3. Myeloid-specific transcriptional activation by murine myeloid zinc-finger protein 2. Murai K, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520388, Free PMC Article
    4. Mzf1 controls cell proliferation and tumorigenesis. Gaboli M, et al. Genes Dev, 2001 Jul 1. PMID 11445537, Free PMC Article
    5. Regulation of myeloid zinc finger protein 2A transactivation activity through phosphorylation by mitogen-activated protein kinases. Ogawa H, et al. J Biol Chem, 2003 Jan 31. PMID 12427756

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway.
      Title: Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway.
    2. Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
      Title: Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
    3. MZF1 down-regulates Mtor expression in pristane-induced plasmacytomas in mice
      Title: The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility.
    4. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
      Title: TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
    5. Findings implicate a novel, temporal-specific role of Mzf1 in embryonic heart development and show that Mzf1 bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.
      Title: Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer.
    6. Data conclude that sell transcription is regulated by Mzf1, Klf2, Sp1, Ets1, and Irf1.
      Title: Transcriptional regulation of mouse L-selectin.
    7. transactivation of this protein is regulated through phosphorylation by mitogen-activated protein kinases.
      Title: Regulation of myeloid zinc finger protein 2A transactivation activity through phosphorylation by mitogen-activated protein kinases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myeloid zinc finger 1
    Names
    Myeloid zinc finger protein 1
    Myeloid zinc finger protein 2
    myeloid-specific retinoic acid-responsive zinc finger protein
    zinc finger protein 121
    zinc finger protein 98

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290452.2 → NP_001277381.1  myeloid zinc finger 1 isoform 2

      See identical proteins and their annotated locations for NP_001277381.1

      Status: VALIDATED

      Source sequence(s)
      AC121301
      UniProtKB/TrEMBL
      A1L357
      Conserved Domains (5) summary
      COG5048
      Location:144 → 524
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:165 → 186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:475 → 500
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001290453.2 → NP_001277382.1  myeloid zinc finger 1 isoform 3

      See identical proteins and their annotated locations for NP_001277382.1

      Status: VALIDATED

      Source sequence(s)
      AC121301
      Conserved Domains (3) summary
      COG5048
      Location:74 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:180 → 200
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001382820.2 → NP_001369749.1  myeloid zinc finger 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121301
      Conserved Domains (1) summary
      smart00431
      Location:42 → 153
      SCAN; leucine rich region

    4. NM_001420326.1 → NP_001407255.1  myeloid zinc finger 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121301
      UniProtKB/TrEMBL
      A1L358

    5. NM_001420327.1 → NP_001407256.1  myeloid zinc finger 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121301

    6. NM_001420329.1 → NP_001407258.1  myeloid zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121301

    7. NM_001420330.1 → NP_001407259.1  myeloid zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121301

    8. NM_001420331.1 → NP_001407260.1  myeloid zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121301

    9. NM_001420332.1 → NP_001407261.1  myeloid zinc finger 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121301

    10. NM_145819.3 → NP_665818.2  myeloid zinc finger 1 isoform 1

      See identical proteins and their annotated locations for NP_665818.2

      Status: VALIDATED

      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS20826.1
      UniProtKB/TrEMBL
      A1L358
      Related
      ENSMUSP00000138387.2, ENSMUST00000182515.8
      Conserved Domains (7) summary
      smart00431
      Location:42 → 153
      SCAN; leucine rich region
      COG5048
      Location:337 → 728
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358 → 379
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 129
      SCAN; SCAN domain
      pfam13465
      Location:668 → 693
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12777074..12792244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539469.4 → XP_006539532.3  myeloid zinc finger 1 isoform X3

      Conserved Domains (1) summary
      smart00431
      Location:121 → 232
      SCAN; leucine rich region

    2. XM_006539465.5 → XP_006539528.1  myeloid zinc finger 1 isoform X1

      See identical proteins and their annotated locations for XP_006539528.1

      UniProtKB/TrEMBL
      S4R1L6
      Related
      ENSMUSP00000138271.2, ENSMUST00000182490.2
      Conserved Domains (4) summary
      smart00431
      Location:121 → 232
      SCAN; leucine rich region
      COG5048
      Location:416 → 807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:623 → 643
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:522 → 542
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006539466.5 → XP_006539529.1  myeloid zinc finger 1 isoform X2

      Conserved Domains (4) summary
      smart00431
      Location:64 → 175
      SCAN; leucine rich region
      COG5048
      Location:359 → 750
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:566 → 586
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:465 → 485
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_017321928.3 → XP_017177417.1  myeloid zinc finger 1 isoform X6

      Conserved Domains (1) summary
      smart00431
      Location:121 → 232
      SCAN; leucine rich region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016793.1: Suppressed sequence

      Description
      NM_016793.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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