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    aakb-2 Association with the SNF1 complex (ASC) domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176552, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aakb-2
    Official Full Name
    Association with the SNF1 complex (ASC) domain-containing protein
    Primary source
    WormBase:WBGene00012928
    Locus tag
    CELE_Y47D3A.15
    See related
    AllianceGenome:WB:WBGene00012928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1) and PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See aakb-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (11237143..11239204)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene AcidPPc domain-containing protein Neighboring gene CMP/dCMP-type deaminase domain-containing protein Neighboring gene ncRNA Neighboring gene Ribosomal protein S6 kinase beta Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential requirements for STRAD in LKB1-dependent functions in C. elegans. Narbonne P, et al. Development, 2010 Feb. PMID 20110331
    2. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Narbonne P, et al. Nature, 2009 Jan 8. PMID 19052547
    3. Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis. Ha MK, et al. Proteomics, 2006 Jun. PMID 16673436
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Association with the SNF1 complex (ASC) domain-containing protein
    NP_499446.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11237143..11239204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067045.3 → NP_499446.1  Association with the SNF1 complex (ASC) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAH7
      Conserved Domains (2) summary
      smart01010
      Location:190 → 274
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:62 → 147
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    Nucleotide Protein
    Heading Accession and Version

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