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    • Showing Current items.

    hex-2 beta-N-acetylhexosaminidase [ Caenorhabditis elegans ]

    Gene ID: 178951, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hex-2
    Official Full Name
    beta-N-acetylhexosaminidase
    Primary source
    WormBase:WBGene00015767
    Locus tag
    CELE_C14C11.3
    See related
    AllianceGenome:WB:WBGene00015767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-N-acetylgalactosaminidase activity. Involved in polysaccharide metabolic process. Is expressed in head neurons; hypodermis; tail neurons; and vulva. Orthologous to human HEXD (hexosaminidase D). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hex-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (5654449..5658699)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene CUB-like domain-containing protein Neighboring gene RNA helicase Neighboring gene YDG domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galactosylated fucose epitopes in nematodes: increased expression in a Caenorhabditis mutant associated with altered lectin sensitivity and occurrence in parasitic species. Yan S, et al. J Biol Chem, 2012 Aug 17. PMID 22733825, Free PMC Article
    2. Enzymatic properties and subtle differences in the substrate specificity of phylogenetically distinct invertebrate N-glycan processing hexosaminidases. Dragosits M, et al. Glycobiology, 2015 Apr. PMID 25488985, Free PMC Article
    3. N-glycan antennal modifications are altered in Caenorhabditis elegans lacking the HEX-4 N-acetylgalactosamine-specific hexosaminidase. Paschinger K, et al. J Biol Chem, 2023 Apr. PMID 36813232, Free PMC Article
    4. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
    5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-N-acetylgalactosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-N-acetylhexosaminidase
    NP_504489.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5654449..5658699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072088.8 → NP_504489.3  beta-N-acetylhexosaminidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504489.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFL1
      Conserved Domains (1) summary
      cd06565
      Location:113 → 433
      GH20_GcnA-like; Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine ...
    Nucleotide Protein
    Heading Accession and Version

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