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    immp-2 Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    immp-2
    Official Full Name
    Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein
    Primary source
    WormBase:WBGene00021925
    Locus tag
    CELE_Y55F3AM.8
    See related
    AllianceGenome:WB:WBGene00021925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See immp-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (1003595..1005861, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene E3 ubiquitin-protein ligase makorin Neighboring gene SPIN90/Ldb17 leucine-rich domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene Ubiquitin-like-conjugating enzyme ATG3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing involved in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial inner membrane peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial inner membrane peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial inner membrane protease subunit 2;Peptidase S26 domain-containing protein
    NP_001368250.1
    • Confirmed by transcript evidence
    NP_500022.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1003595..1005861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067621.4 → NP_500022.1  Mitochondrial inner membrane protease subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N371
      Conserved Domains (2) summary
      cd06530
      Location:27 → 137
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
      TIGR02227
      Location:27 → 145
      sigpep_I_bact; signal peptidase I, bacterial type

    2. NM_001380028.1 → NP_001368250.1  Peptidase S26 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRD7
      Conserved Domains (1) summary
      cd06530
      Location:1 → 103
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
    Nucleotide Protein
    Heading Accession and Version

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