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    nop-1 Pseudocleavage protein nop-1 [ Caenorhabditis elegans ]

    Gene ID: 175845, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nop-1
    Official Full Name
    Pseudocleavage protein nop-1
    Primary source
    WormBase:WBGene00017774
    Locus tag
    CELE_F25B5.2
    See related
    AllianceGenome:WB:WBGene00017774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in anterior/posterior axis specification, embryo and mitotic cytokinesis. Located in cell cortex; cleavage furrow; and nucleus. Is expressed in embryonic cell. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nop-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (5958722..5962325)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase;Putative cytosolic 5'-nucleotidase 3;Transposase Neighboring gene NOPS domain-containing protein;RRM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein dct-6 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudocleavage is dispensable for polarity and development in C. elegans embryos. Rose LS, et al. Dev Biol, 1995 Apr. PMID 7729583
    2. An interphase contractile ring reshapes primordial germ cells to allow bulk cytoplasmic remodeling. Maniscalco C, et al. J Cell Biol, 2020 Feb 3. PMID 31819975, Free PMC Article
    3. LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring. Price KL, et al. Mol Biol Cell, 2017 Sep 1. PMID 28701343, Free PMC Article
    4. RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4. Tse YC, et al. Mol Biol Cell, 2012 Oct. PMID 22918944, Free PMC Article
    5. A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans. Morton DG, et al. Genetics, 2012 Nov. PMID 22887819, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interphase contractile ring reshapes primordial germ cells to allow bulk cytoplasmic remodeling.
      Title: An interphase contractile ring reshapes primordial germ cells to allow bulk cytoplasmic remodeling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pseudocleavage protein nop-1
    NP_001293631.1
    • Confirmed by transcript evidence
    NP_498298.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5958722..5962325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306702.2 → NP_001293631.1  Pseudocleavage protein nop-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      J7H8Z6, Q09314, W6RY41

    2. NM_065897.7 → NP_498298.1  Pseudocleavage protein nop-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498298.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09314
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09314.2

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