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    fog-3 Anti-proliferative protein domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fog-3
    Official Full Name
    Anti-proliferative protein domain-containing protein
    Primary source
    WormBase:WBGene00001483
    Locus tag
    CELE_C03C11.2
    See related
    AllianceGenome:WB:WBGene00001483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription corepressor activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of oocyte development; and spermatogenesis. Located in cytoplasm and nuclear periphery. Is expressed in germ line. Orthologous to several human genes including TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fog-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (10016765..10018121)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein Neighboring gene Protein-tyrosine phosphatase Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel member of the tob family of proteins controls sexual fate in Caenorhabditis elegans germ cells. Chen PJ, et al. Dev Biol, 2000 Jan 1. PMID 10625537
    2. Specification of germ cell fates by FOG-3 has been conserved during nematode evolution. Chen PJ, et al. Genetics, 2001 Aug. PMID 11514443, Free PMC Article
    3. An RNA-Binding Multimer Specifies Nematode Sperm Fate. Aoki ST, et al. Cell Rep, 2018 Jun 26. PMID 29949762, Free PMC Article
    4. Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program. Lee MH, et al. Proc Natl Acad Sci U S A, 2011 May 31. PMID 21571637, Free PMC Article
    5. Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans. Noble DC, et al. Genetics, 2016 Jan. PMID 26564160, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOG-1 and FOG-3 work in a complex to repress oogenic transcripts and thereby promote the sperm fate
      Title: Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans.
    2. FOG-3 can either promote or inhibit proliferation in a manner that is sensitive to both genetic context and gene dosage.
      Title: C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context.
    3. unphosphorylated FOG-3 initiates the sperm fate program and phosphorylated FOG-3 maintains that program for continued sperm production typical of males
      Title: Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in masculinization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Anti-proliferative protein domain-containing protein
    NP_492646.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10016765..10018121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060245.6 → NP_492646.1  Anti-proliferative protein domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDX7
      Conserved Domains (1) summary
      pfam07742
      Location:1 → 109
      BTG; BTG family
    Nucleotide Protein
    Heading Accession and Version

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