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    pdl-1 Phosphodiesterase delta-like protein [ Caenorhabditis elegans ]

    Gene ID: 191741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdl-1
    Official Full Name
    Phosphodiesterase delta-like protein
    Primary source
    WormBase:WBGene00003966
    Locus tag
    CELE_C27H5.1
    See related
    AllianceGenome:WB:WBGene00003966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in sensory perception of light stimulus. Predicted to be active in cytoplasm. Is expressed in nervous system and pharynx. Human ortholog(s) of this gene implicated in Joubert syndrome 22. Orthologous to human PDE6D (phosphodiesterase 6D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pdl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (7183801..7185294)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glutamate-gated ChLoride channel Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene PLD phosphodiesterase domain-containing protein Neighboring gene Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Maduro M, et al. Genetics, 1995 Nov. PMID 8582641, Free PMC Article
    2. GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings. Gross E, et al. J Neurosci, 2014 Dec 10. PMID 25505325, Free PMC Article
    3. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding. Akella JS, et al. Elife, 2020 Feb 26. PMID 32101165, Free PMC Article
    4. Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans. Hukema RK, et al. EMBO J, 2006 Jan 25. PMID 16407969, Free PMC Article
    5. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disrupting pdl-1 in dendrite endings alters the neuron's O2 response properties.
      Title: GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sensory perception of light stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphodiesterase delta-like protein
    NP_495490.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7183801..7185294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063089.3 → NP_495490.1  Phosphodiesterase delta-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18268
      Conserved Domains (1) summary
      pfam05351
      Location:18 → 158
      GMP_PDE_delta; GMP-PDE, delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18268.1

    Gene LinkOut

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