U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pfkb-1.1 6-phosphofructo-2-kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172147, updated on 9-Dec-2024

    Summary

    Official Symbol
    pfkb-1.1
    Official Full Name
    6-phosphofructo-2-kinase domain-containing protein
    Primary source
    WormBase:WBGene00022456
    Locus tag
    CELE_Y110A7A.6
    See related
    AllianceGenome:WB:WBGene00022456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be active in cytosol. Orthologous to several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See pfkb-1.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (5131520..5134105)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp31 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1 Neighboring gene Thymidylate synthase Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    6-phosphofructo-2-kinase domain-containing protein
    NP_001379749.1
    • Confirmed by transcript evidence
    NP_491530.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5131520..5134105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392269.1NP_001379749.1  6-phosphofructo-2-kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N590
      Conserved Domains (2) summary
      pfam00300
      Location:249435
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29246
      6PF2K; 6-phosphofructo-2-kinase
    2. NM_059129.8NP_491530.1  6-phosphofructo-2-kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y85
      Conserved Domains (2) summary
      pfam01591
      Location:35252
      6PF2K; 6-phosphofructo-2-kinase
      pfam00300
      Location:255434
      His_Phos_1; Histidine phosphatase superfamily (branch 1)