asic-1 Degenerin-like protein asic-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: asic-1
Official Full Name: Degenerin-like protein asic-1
Primary source: WormBase:WBGene00022815
Locus tag: CELE_ZK770.1
See related: AllianceGenome:WB:WBGene00022815
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ligand-gated sodium channel activity and pH-gated monoatomic ion channel activity. Involved in positive regulation of dopamine secretion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in XXX cell and neurons. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See asic-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 16

Sequence:: Chromosome: I; NC_003279.8 (3769672..3774005)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors find that ASIC-1, a member of the degenerin/epithelial sodium channel family, which localizes at presynaptic terminals of dopaminergic neurons, is required for associative learning in C. elegans.
Title: A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK770.1 (e-PCR)
- UniSTS:313649

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables pH-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Degenerin-like protein asic-1

NP_491214.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3769672..3774005

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058813.5 → NP_491214.3 Degenerin-like protein asic-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491214.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O01635

Conserved Domains (3) summary

TIGR00867
Location:16 → 779

deg-1; degenerin

pfam00858
Location:17 → 104

ASC; Amiloride-sensitive sodium channel

cl02990
Location:469 → 788

ASC; Amiloride-sensitive sodium channel