glod-4 Glyoxalase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glod-4
Official Full Name: Glyoxalase 1
Primary source: WormBase:WBGene00006448
Locus tag: CELE_C16C10.10
See related: AllianceGenome:WB:WBGene00006448
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in determination of adult lifespan and methylglyoxal metabolic process. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharyngeal-intestinal valve; and seam cell. Orthologous to human GLOD4 (glyoxalase domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glod-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (4153599..4154649)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that, under high glucose conditions, mitochondria-mediated oxidative stress and glycation are downstream targets of ins-7; this impairs neuronal system function and longevity via non-neuronal/neuronal crosstalk by affecting sod-3 and glod-4. (ins-7 = insulin related Probable insulin-like peptide beta-type 4; sod-3 = mitochondrial Mn+2 superoxide dismutase; glod-4 = glyoxalase 1)
Title: Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16C10.10 (e-PCR)
- UniSTS:307255

C16C10.11 (e-PCR)
- UniSTS:315525

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylglyoxal metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: Glyoxalase 1

NP_497827.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4153599..4154649

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065426.5 → NP_497827.1 Glyoxalase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497827.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09253

Conserved Domains (2) summary

cd08358
Location:3 → 127

Glo_EDI_BRP_like_21; This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases

pfam00903
Location:132 → 248

Glyoxalase; Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily