nmy-1 Myosin-11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nmy-1
Official Full Name: Myosin-11
Primary source: WormBase:WBGene00003776
Locus tag: CELE_F52B10.1
See related: AllianceGenome:WB:WBGene00003776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Involved in several processes, including locomotion; nematode larval development; and regulation of embryonic cell shape. Located in adherens junction and contractile muscle fiber. Is expressed in several structures, including anal depressor muscle; head; hypodermis; reproductive system; and tail. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to several human genes including MYH11 (myosin heavy chain 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nmy-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (2909527..2918044)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional nmy-1 and nmy-2 alleles establish that nonmuscle myosins are required for late Caenorhabditis elegans embryonic elongation.
Title: Conditional nmy-1 and nmy-2 alleles establish that nonmuscle myosins are required for late Caenorhabditis elegans embryonic elongation.
Data describe nonmuscle myosins nmy-1 and nmy-2, which are components of the let-502/mel-11 pathway and assist in regulation of embryo elongation in C. elegans.
Title: The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52B10.1 (e-PCR)
- UniSTS:311703

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Myosin-11

NP_001362097.1

Confirmed by transcript evidence

NP_508504.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2909527..2918044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076103.6 → NP_508504.2 Myosin-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508504.2

Status: REVIEWED

UniProtKB/TrEMBL

Q20641

Conserved Domains (4) summary

cd01377
Location:92 → 770

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:80 → 770

Myosin_head; Myosin head (motor domain)

pfam01576
Location:847 → 1919

Myosin_tail_1; Myosin tail

pfam02736
Location:27 → 65

Myosin_N; Myosin N-terminal SH3-like domain
NM_001374981.3 → NP_001362097.1 Myosin-11 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LXR0

Conserved Domains (3) summary

cd01377
Location:92 → 763

MYSc_class_II; class II myosins, motor domain

pfam01576
Location:840 → 1912

Myosin_tail_1; Myosin tail

pfam02736
Location:26 → 65

Myosin_N; Myosin N-terminal SH3-like domain