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    sup-12 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sup-12
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00006321
    Locus tag
    CELE_T22B2.4
    See related
    AllianceGenome:WB:WBGene00006321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. Is expressed in body wall musculature; intestine; non-striated muscle; pharynx; and reproductive system. Orthologous to human RBM24 (RNA binding motif protein 24) and RBM38 (RNA binding motif protein 38). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sup-12 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (3904584..3907673)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neur_chan_memb domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization. Francis GR, et al. J Cell Biol, 1985 Oct. PMID 2413045, Free PMC Article
    2. Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition. Amrane S, et al. Nat Commun, 2014 Sep 3. PMID 25183497
    3. Protein chemical shift assignments of the unbound and RNA-bound forms of the alternative splicing factor SUP-12 from C. elegans. Amrane S, et al. Biomol NMR Assign, 2014 Apr. PMID 23334698
    4. The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans. Anyanful A, et al. J Cell Biol, 2004 Nov 22. PMID 15545320, Free PMC Article
    5. RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing. Kuwasako K, et al. Nat Struct Mol Biol, 2014 Sep. PMID 25132178

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Backbone-independent RNA binding by splicing factor SUP-12 reveals key aspects of molecular recognition.
      Title: Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition.
    2. Determined is the solution structure of a ternary complex of the RNA-recognition motif (RRM) domains from the RBFOX protein ASD-1, SUP-12 and their target RNA from egl-15.
      Title: RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing.
    3. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
      Title: Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
    4. SUP-12, coregulates the egl-15 alternative splicing.
      Title: The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.
    5. SUP-12 is a novel tissue-specific splicing factor
      Title: The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pre-mRNA intronic binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001379963.1
    • Confirmed by transcript evidence
    NP_508674.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3904584..3907673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392755.1 → NP_001379963.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L051
      Conserved Domains (1) summary
      cd12384
      Location:35 → 110
      RRM_RBM24_RBM38_like; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins

    2. NM_076273.5 → NP_508674.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45189
      Conserved Domains (2) summary
      cd12384
      Location:35 → 110
      RRM_RBM24_RBM38_like; RNA recognition motif in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins
      TIGR01661
      Location:37 → 209
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein
    Heading Accession and Version

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