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    rab-6.1 Ras-related protein rab-6.1 [ Caenorhabditis elegans ]

    Gene ID: 176275, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rab-6.1
    Official Full Name
    Ras-related protein rab-6.1
    Primary source
    WormBase:WBGene00004269
    Locus tag
    CELE_F59B2.7
    See related
    AllianceGenome:WB:WBGene00004269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Involved in cortical granule exocytosis and cuticle development. Located in Golgi cisterna and cortical granule. Is expressed in several structures, including RIG; command interneuron; gonad; intestine; and vulva. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rab-6.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9004821..9005955, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative 26S proteasome regulatory subunit rpn-6.2 Neighboring gene Secreted protein Neighboring gene Zinc finger-interacting factor 1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative modeling of Rab6 proteins: identification of key residues and their interactions with guanine nucleotides. Mulukala Narasimha SK, et al. J Mol Model, 2013 Apr. PMID 23334348
    2. Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans. Kimura K, et al. J Cell Sci, 2012 Dec 1. PMID 22992455
    3. RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans. Zhang D, et al. PLoS One, 2016. PMID 26891225, Free PMC Article
    4. The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans. Michaud P, et al. PLoS Genet, 2021 Apr. PMID 33826611, Free PMC Article
    5. The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology. Luo L, et al. Mol Biol Cell, 2011 Jul 15. PMID 21613545, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAB-6.1 is an important molecule for the timely exocytosis of the cortical granules during oocyte-to-embryo transition.
      Title: Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related protein rab-6.1
    NP_498993.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9004821..9005955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066592.7 → NP_498993.1  Ras-related protein rab-6.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34213
      UniProtKB/TrEMBL
      I7EVJ8
      Conserved Domains (2) summary
      smart00175
      Location:12 → 170
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:12 → 172
      Rab6; Rab GTPase family 6 (Rab6)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34213.1

    Gene LinkOut

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