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    hum-4 Myosin motor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181335, updated on 9-Dec-2024

    Summary

    Official Symbol
    hum-4
    Official Full Name
    Myosin motor domain-containing protein
    Primary source
    WormBase:WBGene00002037
    Locus tag
    CELE_F46C3.3
    See related
    AllianceGenome:WB:WBGene00002037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin binding activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be located in cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; actin-based cell projection; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA) and MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hum-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    42
    Sequence:
    Chromosome: X; NC_003284.9 (11420465..11433588, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Myosin motor domain-containing protein
    NP_001257158.1
    • Confirmed by transcript evidence
    NP_001257159.1
    • Confirmed by transcript evidence
    NP_001257161.1
    • Partially confirmed by transcript evidence
    NP_001294791.1
    • Confirmed by transcript evidence
    NP_001294792.1
    • Confirmed by transcript evidence
    NP_001359540.1
    • Confirmed by transcript evidence
    NP_001360186.1
    • Confirmed by transcript evidence
    NP_001379502.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11420465..11433588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373507.3NP_001359540.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20456
      Conserved Domains (7) summary
      smart00015
      Location:680701
      IQ; Calmodulin-binding motif
      smart00139
      Location:21002255
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:22622475
      B41; Band 4.1 homologues
      PRK10263
      Location:11621357
      PRK10263; DNA translocase FtsK; Provisional
      cd14874
      Location:13643
      MYSc_Myo12; class XXXIII myosin, motor domain
      cl17036
      Location:19742030
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:24892563
      PH-like; Pleckstrin homology-like domain
    2. NM_001392845.1NP_001379502.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRJ0
      Conserved Domains (4) summary
      smart00139
      Location:486641
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:648861
      B41; Band 4.1 homologues
      cl17036
      Location:360416
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:875949
      PH-like; Pleckstrin homology-like domain
    3. NM_001270232.4NP_001257161.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6VQ62
      Conserved Domains (5) summary
      smart00139
      Location:523678
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:685898
      B41; Band 4.1 homologues
      pfam00373
      Location:776898
      FERM_M; FERM central domain
      cl17036
      Location:397453
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:912986
      PH-like; Pleckstrin homology-like domain
    4. NM_001373506.3NP_001360186.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F568
      Conserved Domains (7) summary
      smart00015
      Location:680701
      IQ; Calmodulin-binding motif
      smart00139
      Location:20632218
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:22252438
      B41; Band 4.1 homologues
      PRK10263
      Location:11621357
      PRK10263; DNA translocase FtsK; Provisional
      cd14874
      Location:13643
      MYSc_Myo12; class XXXIII myosin, motor domain
      cl17036
      Location:19371993
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:24522526
      PH-like; Pleckstrin homology-like domain
    5. NM_001307862.4NP_001294791.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FD20
      Conserved Domains (7) summary
      smart00139
      Location:8611016
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10231236
      B41; Band 4.1 homologues
      pfam00373
      Location:11141236
      FERM_M; FERM central domain
      pfam15752
      Location:191
      DUF4688; Domain of unknown function (DUF4688)
      pfam17069
      Location:197380
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:735791
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:12501324
      PH-like; Pleckstrin homology-like domain
    6. NM_001270229.4NP_001257158.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT13
      Conserved Domains (6) summary
      smart00139
      Location:8981053
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10601273
      B41; Band 4.1 homologues
      pfam00373
      Location:11511273
      FERM_M; FERM central domain
      pfam17069
      Location:197380
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:772828
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:12871361
      PH-like; Pleckstrin homology-like domain
    7. NM_001307863.4NP_001294792.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZR2
      Conserved Domains (7) summary
      smart00139
      Location:772927
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9341147
      B41; Band 4.1 homologues
      pfam00373
      Location:10251147
      FERM_M; FERM central domain
      pfam15512
      Location:237341
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      pfam17069
      Location:108291
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:646702
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:11611235
      PH-like; Pleckstrin homology-like domain
    8. NM_001270230.4NP_001257159.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT14
      Conserved Domains (6) summary
      smart00139
      Location:809964
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9711184
      B41; Band 4.1 homologues
      pfam00373
      Location:10621184
      FERM_M; FERM central domain
      pfam17069
      Location:108291
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:683739
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:11981272
      PH-like; Pleckstrin homology-like domain