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    parp-2 Poly [ADP-ribose] polymerase 2 [ Caenorhabditis elegans ]

    Gene ID: 3565967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    parp-2
    Official Full Name
    Poly [ADP-ribose] polymerase 2
    Primary source
    WormBase:WBGene00004050
    Locus tag
    CELE_E02H1.4
    See related
    AllianceGenome:WB:WBGene00004050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in double-strand break repair and protein poly-ADP-ribosylation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See parp-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (9593037..9595128)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative dimethyladenosine transferase Neighboring gene putative tRNA pseudouridine synthase tag-124 Neighboring gene Uncharacterized protein Neighboring gene Adenylate kinase isoenzyme 6 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans. Neumann C, et al. J Trace Elem Med Biol, 2020 Jan. PMID 31546209, Free PMC Article
    2. Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival. Dequen F, et al. DNA Repair (Amst), 2005 Jul 12. PMID 15923155
    3. The C. elegans gene pme-5: molecular cloning and role in the DNA-damage response of a tankyrase orthologue. Gravel C, et al. DNA Repair (Amst), 2004 Feb 3. PMID 14706351
    4. Poly(ADP-ribose) metabolism analysis in the nematode Caenorhabditis elegans. St-Laurent JF, et al. Methods Mol Biol, 2011. PMID 21870275
    5. The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Gagnon SN, et al. Biochem J, 2002 Nov 15. PMID 12145714, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Poly [ADP-ribose] polymerase 2
    NP_001022057.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9593037..9595128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026886.6 → NP_001022057.1  Poly [ADP-ribose] polymerase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09525
      Conserved Domains (3) summary
      smart00773
      Location:7 → 89
      WGR; Proposed nucleic acid binding domain
      cd01437
      Location:155 → 527
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:304 → 527
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09525.1

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