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    ddx-52 putative ATP-dependent RNA helicase DDX52 [ Caenorhabditis elegans ]

    Gene ID: 172651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx-52
    Official Full Name
    putative ATP-dependent RNA helicase DDX52
    Primary source
    WormBase:WBGene00011032
    Locus tag
    CELE_R05D11.4
    See related
    AllianceGenome:WB:WBGene00011032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA. Is expressed widely. Orthologous to human DDX52 (DExD-box helicase 52). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddx-52 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (8598658..8600875)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sphingomyelin phosphodiesterase 4 Neighboring gene Partner of xrn-2 protein 1 Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein Neighboring gene DFDF domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screening strategy identifies novel regulators of the proteostasis network. Silva MC, et al. PLoS Genet, 2011 Dec. PMID 22242008, Free PMC Article
    2. Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation. Itani OA, et al. Curr Biol, 2021 Jan 11. PMID 33157031, Free PMC Article
    3. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Garrido-Lecca A, et al. Mol Cell Biol, 2010 Aug. PMID 20498277, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase DDX52
    NP_492326.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8598658..8600875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059925.7 → NP_492326.1  putative ATP-dependent RNA helicase DDX52 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21736
      Conserved Domains (3) summary
      PTZ00424
      Location:124 → 505
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:352 → 478
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:128 → 327
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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