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    pph-7 Tyrosine-protein phosphatase [ Caenorhabditis elegans ]

    Gene ID: 171861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pph-7
    Official Full Name
    Tyrosine-protein phosphatase
    Primary source
    WormBase:WBGene00022110
    Locus tag
    CELE_Y71F9AL.4
    See related
    AllianceGenome:WB:WBGene00022110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pph-7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (2903635..2907757)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coatomer subunit alpha Neighboring gene maleylacetoacetate isomerase Neighboring gene Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein phosphatase
    NP_491071.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2903635..2907757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058670.8 → NP_491071.1  Tyrosine-protein phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4H5
      Conserved Domains (2) summary
      smart00194
      Location:177 → 428
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:199 → 428
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version

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