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    klp-13 Kinesin-like protein [ Caenorhabditis elegans ]

    Gene ID: 180865, updated on 27-Dec-2024

    Summary

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    Official Symbol
    klp-13
    Official Full Name
    Kinesin-like protein
    Primary source
    WormBase:WBGene00002224
    Locus tag
    CELE_F22F4.3
    See related
    AllianceGenome:WB:WBGene00002224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in nervous system. Orthologous to human KIF19 (kinesin family member 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klp-13 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (5984989..5992151)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene cAMP-dependent protein kinase regulatory subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF4265 domain-containing protein Neighboring gene ncRNA Neighboring gene Innexin-3 Neighboring gene CC domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons. Power KM, et al. J Cell Biol, 2024 Sep 2. PMID 38767515, Free PMC Article
    2. CDKL kinase regulates the length of the ciliary proximal segment. Park K, et al. Curr Biol, 2021 Jun 7. PMID 33857430
    3. Metazoan motor models: kinesin superfamily in C. elegans. Siddiqui SS. Traffic, 2002 Jan. PMID 11872139
    4. Muscleblind-1 interacts with tubulin mRNAs to regulate the microtubule cytoskeleton in C. elegans mechanosensory neurons. Puri D, et al. PLoS Genet, 2023 Aug. PMID 37603562, Free PMC Article
    5. Major sperm protein signaling promotes oocyte microtubule reorganization prior to fertilization in Caenorhabditis elegans. Harris JE, et al. Dev Biol, 2006 Nov 1. PMID 16919258

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein
    NP_001360738.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5984989..5992151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373314.3 → NP_001360738.1  Kinesin-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKG7
      Conserved Domains (2) summary
      cl22853
      Location:7 → 328
      Motor_domain; Myosin and Kinesin motor domain
      cl25402
      Location:413 → 513
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein
    Heading Accession and Version

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