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    kel-1 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174791, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kel-1
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00002184
    Locus tag
    CELE_C47D12.7
    See related
    AllianceGenome:WB:WBGene00002184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in g1. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to several human genes including KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See kel-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (11688943..11696059)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase Neighboring gene ERCC4 domain-containing protein Neighboring gene inositol-3-phosphate synthase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. kel-1, a novel Kelch-related gene in Caenorhabditis elegans, is expressed in pharyngeal gland cells and is required for the feeding process. Ohmachi M, et al. Genes Cells, 1999 Jun. PMID 10421842
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_001254310.1
    • Confirmed by transcript evidence
    NP_001254311.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11688943..11696059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267381.2 → NP_001254310.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254310.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGS4
      Conserved Domains (2) summary
      PHA03098
      Location:82 → 603
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:367 → 410
      Kelch; KELCH repeat [structural motif]

    2. NM_001267382.3 → NP_001254311.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7WN97
      Conserved Domains (2) summary
      PHA03098
      Location:1 → 104
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:5 → 46
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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