ima-2 Importin subunit alpha-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ima-2
Official Full Name: Importin subunit alpha-2
Primary source: WormBase:WBGene00002073
Locus tag: CELE_F26B1.3
See related: AllianceGenome:WB:WBGene00002073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables nuclear import signal receptor activity. Involved in several processes, including meiotic sister chromatid cohesion; mitotic nuclear membrane reassembly; and protein import into nucleus. Located in cytoplasm and nuclear envelope. Is expressed in Z2; Z3; and germ line. Orthologous to human KPNA2 (karyopherin subunit alpha 2) and KPNA7 (karyopherin subunit alpha 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ima-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (6315233..6317262)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ima-2 interacts with akir-1 to regulate meiotic chromatid cohesion in the germline.
Title: A Novel Role for α-Importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans.
IMA-2 is required for proper chromosome dynamics in germ line and early embryonic mitosis and is involved in nuclear envelope assembly at the conclusion of mitosis
Title: A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis.
both IMA-2 and IMB-1, the homologues of vertebrate importin alpha and beta, are essential for both spindle assembly and nuclear formation in early embryos
Title: Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26B1.6 (e-PCR)
- UniSTS:313097

F26B1.3 (e-PCR)
- UniSTS:309958

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear import signal receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic nuclear membrane reassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Importin subunit alpha-2

NP_491824.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6315233..6317262

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059423.8 → NP_491824.1 Importin subunit alpha-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491824.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91276

Conserved Domains (5) summary

COG5064
Location:21 → 522

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:126 → 248

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:21 → 103

IBB; Importin beta binding domain

pfam16186
Location:470 → 517

Arm_3; Atypical Arm repeat

sd00043
Location:128 → 159

ARM; armadillo repeat [structural motif]