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    pas-2 Proteasome subunit alpha type-2 [ Caenorhabditis elegans ]

    Gene ID: 179493, updated on 2-Nov-2024

    Summary

    Official Symbol
    pas-2
    Official Full Name
    Proteasome subunit alpha type-2
    Primary source
    WormBase:WBGene00003923
    Locus tag
    CELE_D1054.2
    See related
    AllianceGenome:WB:WBGene00003923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See pas-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (10770368..10771351)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein;Ion transport domain-containing protein Neighboring gene ncRNA Neighboring gene PNPLA domain-containing protein Neighboring gene SGS domain-containing protein Neighboring gene ncRNA Neighboring gene CBS domain-containing protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Proteasome subunit alpha type-2
    NP_505750.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10770368..10771351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073349.9NP_505750.1  Proteasome subunit alpha type-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27488
      Conserved Domains (2) summary
      PRK03996
      Location:10228
      PRK03996; proteasome subunit alpha; Provisional
      cd03750
      Location:5229
      proteasome_alpha_type_2; proteasome_alpha_type_2. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...