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    rnr-2 Ribonucleoside-diphosphate reductase small chain [ Caenorhabditis elegans ]

    Gene ID: 175525, updated on 2-Nov-2024

    Summary

    Official Symbol
    rnr-2
    Official Full Name
    Ribonucleoside-diphosphate reductase small chain
    Primary source
    WormBase:WBGene00004392
    Locus tag
    CELE_C03C10.3
    See related
    AllianceGenome:WB:WBGene00004392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in embryo development. Predicted to be active in cytosol. Is expressed in gonad and intestine. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to several human genes including RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See rnr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (4093308..4094921, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Casein kinase I isoform alpha Neighboring gene Uncharacterized protein Neighboring gene Putative casein kinase I C03C10.2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Guanine nucleotide exchange factor rei-1 Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    Ribonucleoside-diphosphate reductase small chain
    NP_497821.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4093308..4094921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065420.9NP_497821.1  Ribonucleoside-diphosphate reductase small chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497821.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42170
      Conserved Domains (1) summary
      cl00264
      Location:62381
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins