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    gpa-9 Guanine nucleotide-binding protein alpha-9 subunit [ Caenorhabditis elegans ]

    Gene ID: 191659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-9
    Official Full Name
    Guanine nucleotide-binding protein alpha-9 subunit
    Primary source
    WormBase:WBGene00001671
    Locus tag
    CELE_F56H9.4
    See related
    AllianceGenome:WB:WBGene00001671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in ASJ; lumbar neurons; pharyngeal muscle cell; and spermatheca. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-9 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (12645477..12649313, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 30S ribosomal protein S16;Venom peptide Neighboring gene Guanine nucleotide-binding protein alpha-8 subunit Neighboring gene ShKT domain-containing protein Neighboring gene Protein lin-25 Neighboring gene M247R Neighboring gene C3H1-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans. Hahm JH, et al. Aging Cell, 2011 Apr. PMID 21108728
    2. Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans. Meisel JD, et al. Curr Biol, 2016 Jul 25. PMID 27397889, Free PMC Article
    3. Signaling proteins that regulate NaCl [corrected] chemotaxis responses modulate longevity in C. elegans. Lans H, et al. Ann N Y Acad Sci, 2009 Jul. PMID 19686212
    4. Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Lans H, et al. Dev Biol, 2007 Mar 15. PMID 17187771
    5. G proteins, chemosensory perception, and the C. elegans genome project: An attractive story. Wilkie TM. Bioessays, 1999 Sep. PMID 10462410

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identify GPA-9 as a novel regulator of both the immune system and aging in C. elegans.
      Title: GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Guanine nucleotide-binding protein alpha-9 subunit
    NP_001256444.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12645477..12649313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269515.3 → NP_001256444.1  Guanine nucleotide-binding protein alpha-9 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G3MU18, G3MU19, Q20910
      Conserved Domains (1) summary
      cl21455
      Location:2 → 91
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_132533.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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