U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    wht-3 ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175528, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    wht-3
    Official Full Name
    ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein
    Primary source
    WormBase:WBGene00007631
    Locus tag
    CELE_C16C10.12
    See related
    AllianceGenome:WB:WBGene00007631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See wht-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (4147425..4151598, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hemiasterlin resistant protein 1 Neighboring gene Glyoxalase 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans. Ferrier A, et al. PLoS One, 2011. PMID 22073173, Free PMC Article
    2. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
    3. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein
    NP_001309589.1
    • Confirmed by transcript evidence
    NP_001309590.1
    • Confirmed by transcript evidence
    NP_001309591.1
    • Confirmed by transcript evidence
    NP_497825.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4147425..4151598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065424.3 → NP_497825.2  ABC transporter ATP-binding protein/permease wht-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09466
      Conserved Domains (3) summary
      cd03213
      Location:36 → 263
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:37 → 614
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:351 → 555
      ABC2_membrane; ABC-2 type transporter

    2. NM_001322779.3 → NP_001309589.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09466
      UniProtKB/TrEMBL
      A0A131MAX2
      Conserved Domains (1) summary
      TIGR00955
      Location:37 → 600
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

    3. NM_001322780.3 → NP_001309591.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09466
      UniProtKB/TrEMBL
      A0A131MCE2
      Conserved Domains (3) summary
      TIGR00955
      Location:1 → 528
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:265 → 469
      ABC2_membrane; ABC-2 type transporter
      cl21455
      Location:3 → 177
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001322781.3 → NP_001309590.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09466
      UniProtKB/TrEMBL
      A0A131MBH6
      Conserved Domains (1) summary
      TIGR00955
      Location:1 → 542
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools