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    snf-11 Transporter [ Caenorhabditis elegans ]

    Gene ID: 191770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snf-11
    Official Full Name
    Transporter
    Primary source
    WormBase:WBGene00004910
    Locus tag
    CELE_T03F7.1
    See related
    AllianceGenome:WB:WBGene00004910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in gamma-aminobutyric acid transport. Located in neuron projection and neuronal cell body. Is expressed in body wall musculature; enteric muscle; head mesodermal cell; nervous system; and uterine muscle. Human ortholog(s) of this gene implicated in alcohol dependence and myoclonic-atonic epilepsy. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snf-11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (11305070..11308446, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons. Schultheis C, et al. J Neurophysiol, 2011 Aug. PMID 21613582, Free PMC Article
    2. The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA. Mullen GP, et al. Mol Biol Cell, 2006 Jul. PMID 16641366, Free PMC Article
    3. Expression pattern determines regulatory logic. Mora-Martinez C. PLoS One, 2021. PMID 33395445, Free PMC Article
    4. MPMT-OX up-regulates GABAergic transmission and protects against seizure-like behavior in Caenorhabditis elegans. Câmara DF, et al. Neurotoxicology, 2019 Sep. PMID 31415799
    5. A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function. Jiang G, et al. J Biol Chem, 2005 Jan 21. PMID 15542610

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The localization of SNF-11 is consistent with a GABA clearance function rather than recycling.
      Title: The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Transporter
    NP_505873.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11305070..11308446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073472.8 → NP_505873.2  Transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505873.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF43
      Conserved Domains (1) summary
      cd11496
      Location:10 → 586
      SLC6sbd-TauT-like; Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version

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