Ifna4 interferon alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifna4provided by MGI
Official Full Name: interferon alpha 4provided by MGI
Primary source: MGI:MGI:107664
See related: Ensembl:ENSMUSG00000070904 AllianceGenome:MGI:107664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifa4; If1ai13
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Acts upstream of or within defense response to virus and natural killer cell activation involved in immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA1 (interferon alpha 1); IFNA10 (interferon alpha 10); and IFNA13 (interferon alpha 13). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 4 C4; 4 42.03 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (88760032..88761009)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (88841816..88842459)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Infecting virus and the target cell type dictate the extent and signature of inducible IFN-alpha4 gene expression.
Title: Distinct signature type I interferon responses are determined by the infecting virus and the target cell.
Activation of the Akt pathway by the IFN receptors complements the function of IFN-activated JAK-STAT pathways, by allowing mRNA translation of IFN-stimulated genes and, ultimately, the induction of the biological effects of IFNs.
Title: Role of the Akt pathway in mRNA translation of interferon-stimulated genes.
Data describe the species specificity of IFN-alphas, the residues in murine IFN-alpha4 that preclude strong affinity interactions with human IFNAR1 and 2, and residues in human IFN-alpha8 that resemble a receptor interactive domain in murine IFN-alpha4.
Title: A structural basis for interferon-alpha-receptor interactions.
Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription
Title: Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription.
IFN regulatory factor-3 is a component of virus-induced factor which binds the virus responsive element VRE-A4 in the IFNA4 promotor
Title: The virus-induced factor VIF differentially recognizes the virus-responsive modules of the mouse IFNA4 gene promoter.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifna7 (e-PCR), detects polymorphism
- UniSTS:516867

NoName (e-PCR)
- UniSTS:491332

Ifna1 (e-PCR), detects polymorphism
- UniSTS:143457

NoName (e-PCR)
- UniSTS:493055

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info
enables type I interferon receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within natural killer cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon alpha-4

Names: IFN-alpha-4; MuIFN-alpha 4; interferon 1ai13; interferon alpha family, gene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.