Slc30a6 solute carrier family 30 (zinc transporter), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a6provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 6provided by MGI
Primary source: MGI:MGI:2386741
See related: Ensembl:ENSMUSG00000024069 AllianceGenome:MGI:2386741
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZnT6; 9530029F08Rik
Summary: Enables zinc ion transmembrane transporter activity. Acts upstream of or within Golgi to endosome transport and zinc ion transport. Located in mitochondrion. Is expressed in embryo. Orthologous to human SLC30A6 (solute carrier family 30 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 12.8), large intestine adult (RPKM 9.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E2; 17 45.64 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (74702573..74731225)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (74395578..74424229)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results revealed that ZNT7 immunoreactivity was abundantly expressed in the nerve cells of the mouse DRG.Double immunofluorescence labeling of ZNT7 and TGN38 revealed a colocalization of the two antigens in the Golgi apparatus.
Title: Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia.
overexpression of ZnT6 causes growth inhibition, znT6 functions in zinc homeostasis and transport
Title: Functional characterization of a novel mammalian zinc transporter, ZnT6.
There were no differences between the mRNA expression levels of ZnT family members in undifferentiated Rcho-1 cells and differentiated Rcho-1 cells.
Title: Expression profiles of zinc transporters in rodent placental models.
Expression of zinc transporter ZnT6 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Title: Dynamic zinc pools in mouse choroid plexus.
Increased ZnT-6 immunostaining in neurons containing cytoplasmic inclusions in MCI, AD, and PD suggests a role for ZnT-6 in the pathogenesis of these lesions.
Title: Elevated zinc transporter-6 in mild cognitive impairment, Alzheimer disease, and pick disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc30a6 (e-PCR), detects polymorphism
- UniSTS:547334

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to endosome transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of zinc ion transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc transporter 6

Names: solute carrier family 30 (zinc transporter), member 4; solute carrier family 30 member 6; zinc transporter-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252478.1 → NP_001239407.1 zinc transporter 6 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC169506, AK160903, CT033749

Consensus CDS

CCDS57109.1

UniProtKB/TrEMBL

J3QMX8

Related

ENSMUSP00000136503.2, ENSMUST00000179074.9

Conserved Domains (2) summary

COG1230
Location:83 → 336

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:43 → 260

Cation_efflux; Cation efflux family
NM_144798.6 → NP_659047.2 zinc transporter 6 isoform 2

See identical proteins and their annotated locations for NP_659047.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC169506, AK082907, CT033749

Consensus CDS

CCDS37691.1

UniProtKB/Swiss-Prot

Q3UB35, Q6NVE0, Q8BJM5, Q8K4H6, Q8R4Z2, Q99JQ3

Related

ENSMUSP00000024870.7, ENSMUST00000024870.9

Conserved Domains (2) summary

COG1230
Location:55 → 331

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:43 → 255

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

74702573..74731225

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160430.1 → XP_036016323.1 zinc transporter 6 isoform X1

Conserved Domains (1) summary

pfam01545
Location:43 → 255

Cation_efflux; Cation efflux family
XM_017317374.2 → XP_017172863.1 zinc transporter 6 isoform X3

Conserved Domains (1) summary

COG1230
Location:55 → 291

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
XM_036160431.1 → XP_036016324.1 zinc transporter 6 isoform X2

Conserved Domains (1) summary

COG1230
Location:51 → 180

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]