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    rab-19 Ras-related protein Rab-10 [ Caenorhabditis elegans ]

    Gene ID: 178301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab-19
    Official Full Name
    Ras-related protein Rab-10
    Primary source
    WormBase:WBGene00004278
    Locus tag
    CELE_Y62E10A.9
    See related
    AllianceGenome:WB:WBGene00004278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and plasma membrane bounded cell projection. Predicted to be active in endomembrane system. Is expressed in anal depressor muscle and excretory cell. Orthologous to several human genes including RAB43 (RAB43, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rab-19 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (13382061..13383957, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene NADPH:adrenodoxin oxidoreductase, mitochondrial Neighboring gene Phosducin domain-containing protein;Phosducin thioredoxin-like domain-containing protein Neighboring gene ER membrane protein complex subunit 3 Neighboring gene Tim44-like domain-containing protein Neighboring gene Mediator complex subunit 9 Neighboring gene Guanine nucleotide exchange factor MSS4 Neighboring gene U6 snRNA-associated Sm-like protein LSm3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans. Hannemann M, et al. PLoS Genet, 2012. PMID 22654674, Free PMC Article
    2. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Li P, et al. Neuron, 2016 May 4. PMID 27151641, Free PMC Article
    3. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    4. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article
    5. ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. Kao G, et al. Cell, 2007 Feb 9. PMID 17289575

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in localization within membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related protein Rab-10
    NP_001370091.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13382061..13383957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383234.2 → NP_001370091.1  Ras-related protein Rab-10 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7FN72, Q9U1W9
      Conserved Domains (1) summary
      cd01864
      Location:8 → 172
      Rab19; Rab GTPase family 19 (Rab19)
    Nucleotide Protein
    Heading Accession and Version

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