pqn-15 Prion-like-(Q/N-rich)-domain-bearing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pqn-15
Official Full Name: Prion-like-(Q/N-rich)-domain-bearing protein
Primary source: WormBase:WBGene00004106
Locus tag: CELE_C24A8.3
See related: AllianceGenome:WB:WBGene00004106
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Predicted to be involved in heterochromatin formation and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pqn-15 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (4297869..4306961, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C24A8.3 (e-PCR)
- UniSTS:309131

C52B9.8 (e-PCR)
- UniSTS:309392

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Prion-like-(Q/N-rich)-domain-bearing protein

NP_001367558.1

Product from WormBase gene class pqn;
Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4297869..4306961 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380945.1 → NP_001367558.1 Prion-like-(Q/N-rich)-domain-bearing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

P91094

Conserved Domains (3) summary

smart00573
Location:1011 → 1083

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:1062 → 1726

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

pfam09606
Location:1 → 288

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal