let-413 PDZ domain-containing protein;Protein Scribble homolog let-413 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: let-413
Official Full Name: PDZ domain-containing protein;Protein Scribble homolog let-413
Primary source: WormBase:WBGene00002632
Locus tag: CELE_F26D11.11
See related: AllianceGenome:WB:WBGene00002632
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Is expressed in epithelial cell; nerve ring; rectum; and spermatheca. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See let-413 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (7973078..7977776, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LET-413 is required for DENN-4-mediated RAB-10 activation, and the LET-413-assisted RAB-5 to RAB-10 cascade contributes to the integrity of C. elegans intestinal epithelia.
Title: LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling.
requirement for LET-413 and DLG-1 in the polarization of the spermathecal cells
Title: Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly.
These results represent the first in vivo analysis of requirements for the L27 domain of a Discs-large/SAP97 protein, identify a crucial LET-413/Scribble regulatory motif.
Title: Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F26D11.11 (e-PCR)
- UniSTS:312302

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in actin filament-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of intermediate filament polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: PDZ domain-containing protein;Protein Scribble homolog let-413

NP_001023851.1

Confirmed by transcript evidence

NP_001362012.1

Confirmed by transcript evidence

NP_001362181.1

Confirmed by transcript evidence

NP_001362182.1

Confirmed by transcript evidence

NP_001362183.1

Confirmed by transcript evidence

NP_001362184.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7973078..7977776 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001374916.3 → NP_001362181.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1IC26

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:574 → 661

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001028680.7 → NP_001023851.1 Protein Scribble homolog let-413 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023851.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61967, Q6A580, Q9NFN7

Conserved Domains (5) summary

COG0265
Location:590 → 659

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00116
Location:37 → 349

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:567 → 654

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:59 → 117

LRR_8; Leucine rich repeat
NM_001374915.3 → NP_001362182.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1IAV7

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:574 → 652

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001374914.3 → NP_001362183.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1I804

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:567 → 645

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001374918.2 → NP_001362012.1 Protein Scribble homolog let-413 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:574 → 661

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001374917.4 → NP_001362184.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1I8A6

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:567 → 654

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]