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    igdb-2 Ig-like and fibronectin type-III domain-containing protein 2 [ Caenorhabditis elegans ]

    Gene ID: 178199, updated on 27-Dec-2024

    Summary

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    Official Symbol
    igdb-2
    Official Full Name
    Ig-like and fibronectin type-III domain-containing protein 2
    Primary source
    WormBase:WBGene00007736
    Locus tag
    CELE_C25G4.10
    See related
    AllianceGenome:WB:WBGene00007736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in sarcomere organization. Predicted to be located in plasma membrane. Predicted to be active in M band. Is expressed in amphid sheath cell; amphid socket cell; and hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See igdb-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (12468659..12475177)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phenazine biosynthesis-like domain-containing protein Neighboring gene Phenazine biosynthesis-like domain-containing protein Neighboring gene Ig-like and fibronectin type-III domain-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IGDB-2, an Ig/FNIII protein, binds the ion channel LGC-34 and controls sensory compartment morphogenesis in C. elegans. Wang W, et al. Dev Biol, 2017 Oct 1. PMID 28803967, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ig-like and fibronectin type-III domain-containing protein 2
    NP_001255649.1
    • Confirmed by transcript evidence
    NP_001255650.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12468659..12475177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268720.4 → NP_001255649.1  Ig-like and fibronectin type-III domain-containing protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1P642, O18023, Q18174, Q95ZY5
      Conserved Domains (5) summary
      smart00060
      Location:1315 → 1392
      FN3; Fibronectin type 3 domain
      cd00063
      Location:825 → 911
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00047
      Location:1125 → 1198
      ig; Immunoglobulin domain
      pfam01682
      Location:484 → 577
      DB; DB module
      pfam14625
      Location:684 → 724
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain

    2. NM_001268721.3 → NP_001255650.1  Ig-like and fibronectin type-III domain-containing protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255650.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18023
      Conserved Domains (3) summary
      smart00410
      Location:137 → 169
      IG_like; Immunoglobulin like
      pfam01682
      Location:189 → 280
      DB; DB module
      cl11960
      Location:133 → 159
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18023.4

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