hcf-1 Host cell factor homolog hcf-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hcf-1
Official Full Name: Host cell factor homolog hcf-1
Primary source: WormBase:WBGene00001827
Locus tag: CELE_C46A5.9
See related: AllianceGenome:WB:WBGene00001827
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Is expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Orthologous to human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hcf-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (7770770..7774275, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
Title: The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation
Title: Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.
Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.
Title: Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.
HCF-1 proteins possess conserved roles in the regulation of cell division and mitotic histone phosphorylation
Title: Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
Purifed HCF can support herpes simplex virus VP16-induced complex formation in the presence of bacterially expressed VP16 and Oct-1 proteins
Title: Purification and characterization of the Caenorhabditis elegans HCF protein and domains of human HCF.
Data show that the last 23 amino acids of nematode HCF-1 (host cell factor 1) are involved in both nuclear and mitochondrial targeting.
Title: A C-terminal targeting signal controls differential compartmentalisation of Caenorhabditis elegans host cell factor (HCF) to the nucleus or mitochondria.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C46A5.9 (e-PCR)
- UniSTS:308787

C33H5.7 (e-PCR)
- UniSTS:308702

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in dauer exit	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to other organism	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by transcription factor localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Host cell factor homolog hcf-1

NP_501279.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7770770..7774275 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068878.5 → NP_501279.1 Host cell factor homolog hcf-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501279.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC23

Conserved Domains (7) summary

smart00060
Location:641 → 739

FN3; Fibronectin type 3 domain

cd00063
Location:606 → 635

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:212 → 267

Kelch; KELCH repeat [structural motif]

pfam01344
Location:43 → 81

Kelch_1; Kelch motif

pfam09184
Location:488 → 546

PPP4R2; PPP4R2

pfam13415
Location:102 → 155

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:334 → 376

Kelch_5; Kelch motif