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    unc-52 Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175126, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-52
    Official Full Name
    Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein
    Primary source
    WormBase:WBGene00006787
    Locus tag
    CELE_ZC101.2
    See related
    AllianceGenome:WB:WBGene00006787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    An extracellular matrix structural constituent. Involved in several processes, including hemidesmosome assembly; muscle cell cellular homeostasis; and nematode pharyngeal gland morphogenesis. Located in basement membrane and striated muscle dense body. Is expressed in several structures, including intestine; non-striated muscle; pharyngeal-intestinal valve; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-52 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    48
    Sequence:
    Chromosome: II; NC_003280.10 (14647321..14684456, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class epsilon-13 Neighboring gene ncRNA Neighboring gene Aamy domain-containing protein;Glycosyl hydrolase family 13 catalytic domain-containing protein Neighboring gene ncRNA Neighboring gene Protein-cysteine N-palmitoyltransferase HHAT Neighboring gene DUF148 domain-containing protein;Phage protein Neighboring gene Uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables extracellular matrix structural constituent PubMed 
    enables structural molecule activity PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in cell differentiation  
    involved_in cell migration PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in fibroblast growth factor receptor signaling pathway PubMed 
    involved_in hemidesmosome assembly PubMed 
    involved_in locomotion PubMed 
    involved_in mitochondrion organization PubMed 
    involved_in muscle cell cellular homeostasis PubMed 
    involved_in muscle organ development PubMed 
    involved_in muscle organ morphogenesis PubMed 
    involved_in myofibril assembly PubMed 
    involved_in nematode larval development PubMed 
    involved_in nematode pharyngeal gland morphogenesis PubMed 
    involved_in nematode pharynx development PubMed 
    involved_in positive regulation of locomotion PubMed 
    involved_in positive regulation of ovulation PubMed 
    involved_in positive regulation of sarcomere organization PubMed 
    Component Evidence Code Pubs
    located_in M band  
    located_in basement membrane PubMed 
    located_in basement membrane  
    located_in cytoplasm  
    located_in extracellular matrix PubMed 
    located_in extracellular region  
    located_in striated muscle dense body PubMed 

    General protein information

    Preferred Names
    Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein
    NP_001022488.1
    • Confirmed by transcript evidence
    NP_001254438.1
    • Confirmed by transcript evidence
    NP_001254439.1
    • Confirmed by transcript evidence
    NP_001254440.1
    • Confirmed by transcript evidence
    NP_001254442.1
    • Confirmed by transcript evidence
    NP_001254443.1
    • Confirmed by transcript evidence
    NP_001254444.1
    • Confirmed by transcript evidence
    NP_001254445.1
    • Confirmed by transcript evidence
    NP_001254446.1
    • Partially confirmed by transcript evidence
    NP_001293585.1
    • Confirmed by transcript evidence
    NP_001337294.1
    • Confirmed by transcript evidence
    NP_001364664.1
    • Confirmed by transcript evidence
    NP_497044.3
    • Confirmed by transcript evidence
    NP_497045.1
    • Confirmed by transcript evidence
    NP_497046.1
    • Confirmed by transcript evidence
    NP_497047.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14647321..14684456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377905.2 → NP_001364664.1  Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEI5
      Conserved Domains (16) summary
      cd05743
      Location:1075 → 1152
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
      smart00180
      Location:1172 → 1218
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:1578 → 1702
      LamB; Laminin B domain
      smart00282
      Location:3513 → 3644
      LamG; Laminin G domain
      smart00409
      Location:1932 → 2012
      IG; Immunoglobulin
      smart00410
      Location:2404 → 2486
      IG_like; Immunoglobulin like
      cd00054
      Location:3411 → 3448
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:3882 → 4040
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:416 → 450
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00053
      Location:1748 → 1795
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:1020 → 1057
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13927
      Location:2673 → 2756
      Ig_3; Immunoglobulin domain
      cd00096
      Location:3070 → 3077
      Ig; Ig strand B [structural motif]
      cd05754
      Location:834 → 919
      IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      cl00104
      Location:977 → 1013
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:3067 → 3137
      Ig; Immunoglobulin domain
    2. NM_064643.10 → NP_497044.3  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497044.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18261, O18263, Q06561, Q6BEQ6, Q9U7E8, Q9XTD2, Q9XTI5
      Conserved Domains (16) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2366 → 2427
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00282
      Location:2813 → 2944
      LamG; Laminin G domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      cd00054
      Location:2711 → 2748
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:3182 → 3340
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1599 → 1683
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    3. NM_001267509.3 → NP_001254438.1  Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K109
      Conserved Domains (4) summary
      smart00282
      Location:314 → 445
      LamG; Laminin G domain
      cd00054
      Location:212 → 249
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:683 → 841
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:255 → 284
      EGF; EGF-like domain
    4. NM_064645.6 → NP_497046.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497046.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06561
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2366 → 2427
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1599 → 1683
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    5. NM_001027317.8 → NP_001022488.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06561
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2273 → 2334
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1327 → 1407
      IG; Immunoglobulin
      smart00410
      Location:1139 → 1219
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1325 → 1400
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1506 → 1590
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    6. NM_064644.6 → NP_497045.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497045.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06561
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2179 → 2240
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1599 → 1683
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    7. NM_001267515.3 → NP_001254444.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G348
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2267 → 2328
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1228 → 1312
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    8. NM_001267516.3 → NP_001254445.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254445.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G349
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2272 → 2333
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1599 → 1683
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    9. NM_001267517.3 → NP_001254446.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G350
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2363 → 2424
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1420 → 1500
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1599 → 1683
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    10. NM_001267513.3 → NP_001254442.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254442.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G353
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2080 → 2141
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1228 → 1312
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    11. NM_001267514.4 → NP_001254443.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254443.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G354
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2173 → 2234
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1512 → 1593
      IG; Immunoglobulin
      smart00410
      Location:1232 → 1312
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1418 → 1493
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1228 → 1312
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    12. NM_001350388.3 → NP_001337294.1  Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUZ1
      Conserved Domains (14) summary
      cd05743
      Location:1075 → 1152
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:834 → 919
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00408
      Location:3155 → 3216
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:1172 → 1218
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:1574 → 1698
      LamB; Laminin B domain
      smart00409
      Location:2021 → 2101
      IG; Immunoglobulin
      smart00410
      Location:2301 → 2382
      IG_like; Immunoglobulin like
      cd00112
      Location:416 → 450
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00053
      Location:1744 → 1791
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:1020 → 1057
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      cl00104
      Location:977 → 1013
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam13895
      Location:2387 → 2472
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:2674 → 2747
      Ig_3; Immunoglobulin domain
      cl11960
      Location:1919 → 2007
      Ig; Immunoglobulin domain
    13. NM_001267510.3 → NP_001254439.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G352
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2077 → 2138
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:496 → 620
      LamB; Laminin B domain
      smart00409
      Location:1223 → 1304
      IG; Immunoglobulin
      smart00410
      Location:943 → 1023
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1129 → 1204
      ig; Immunoglobulin domain
      pfam00053
      Location:666 → 713
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1310 → 1394
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    14. NM_001267511.3 → NP_001254440.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G351
      Conserved Domains (13) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00408
      Location:2180 → 2241
      IGc2; Immunoglobulin C-2 Type
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      smart00409
      Location:1326 → 1407
      IG; Immunoglobulin
      smart00410
      Location:1234 → 1314
      IG_like; Immunoglobulin like
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:1232 → 1307
      ig; Immunoglobulin domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:1413 → 1497
      Ig_2; Immunoglobulin domain
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain
    15. NM_001306656.3 → NP_001293585.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PS79
      Conserved Domains (1) summary
      smart00408
      Location:21 → 82
      IGc2; Immunoglobulin C-2 Type
    16. NM_064646.7 → NP_497047.1  Basement membrane proteoglycan [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06561
      Conserved Domains (8) summary
      cd05743
      Location:286 → 363
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      smart00180
      Location:383 → 429
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:785 → 909
      LamB; Laminin B domain
      pfam07679
      Location:271 → 356
      I-set; Immunoglobulin I-set domain
      pfam00053
      Location:955 → 1002
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:231 → 268
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      cl00104
      Location:188 → 224
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl11960
      Location:45 → 130
      Ig; Immunoglobulin domain

    RNA

    1. NR_131430.1 RNA Sequence

      Status: REVIEWED

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