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    arf-5 ADP-ribosylation factor [ Caenorhabditis elegans ]

    Gene ID: 177595, updated on 27-Dec-2024

    Summary

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    Official Symbol
    arf-5
    Official Full Name
    ADP-ribosylation factor
    Primary source
    WormBase:WBGene00000183
    Locus tag
    CELE_F57H12.1
    See related
    AllianceGenome:WB:WBGene00000183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Involved in embryo development and germ cell development. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including intestine; pharyngeal muscle cell; seam cell; ventral nerve cord; and vulva. Orthologous to several human genes including ARF5 (ARF GTPase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See arf-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (7982526..7983852)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Band 7 domain-containing protein Neighboring gene ncRNA Neighboring gene Alpha-tubulin N-acetyltransferase 1;N-acetyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Padovan-Merhar O, et al. Mol Cell, 2015 Apr 16. PMID 25866248, Free PMC Article
    2. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Dang H, et al. Mol Biol Cell, 2004 Jan. PMID 14565969, Free PMC Article
    3. Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. Li Y, et al. FASEB J, 2004 Dec. PMID 15576487
    4. Loss of MEC-17 leads to microtubule instability and axonal degeneration. Neumann B, et al. Cell Rep, 2014 Jan 16. PMID 24373971, Free PMC Article
    5. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. Skorobogata O, et al. PLoS Genet, 2014 Oct. PMID 25329472, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An AGEF-1/Arf-3 GTPase/AP-1 ensemble antagonizes LET-23 basolateral localization and signaling during C. elegans vulva induction.
      Title: An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor
    NP_501336.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7982526..7983852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068935.7 → NP_501336.1  ADP-ribosylation factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK4
      Conserved Domains (2) summary
      smart00178
      Location:15 → 174
      SAR; Sar1p-like members of the Ras-family of small GTPases
      cl21455
      Location:1 → 179
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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